General Information

  • ID:  hor005228
  • Uniprot ID:  B3EWY3
  • Protein name:  Natriuretic peptide Coa_NP1
  • Gene name:  NA
  • Organism:  Crotalus oreganus abyssus (Grand Canyon rattlesnake) (Crotalus abyssus)
  • Family:  Natriuretic peptide family, Snake NP subfamily
  • Source:  Animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Crotalus oreganus (species), Crotalus (genus), Crotalinae (subfamily), Viperidae (family), Colubroidea (superfamily), Serpentes (infraorder), Toxicofera, Episquamata, Unidentata, Bifurcata, Squamata (order), Lepidosauria (class), Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0090729 toxin activity
  • GO BP:  GO:0007165 signal transduction; GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SKRLSNGCFGLKLDRIGAMSGLGCWRLINESK
  • Length:  32(1-32)
  • Propeptide:  SKRLSNGCFGLKLDRIGAMSGLGCWRLINESK
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Exhibits hypotensive and vasodepressor activity
  • Mechanism:  Negative results: vasodilation does not appear to be mediated by the natriuretic peptide receptor-A (NPR1) (Ref.1).
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  45893
  • Structure ID:  AF-B3EWY3-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-B3EWY3-F1.pdbhor005228_AF2.pdbhor005228_ESM.pdb

Physical Information

Mass: 406427 Formula: C151H253N47O43S3
Absent amino acids: HPQTVY Common amino acids: GL
pI: 10.5 Basic residues: 6
Polar residues: 13 Hydrophobic residues: 10
Hydrophobicity: -18.13 Boman Index: -5265
Half-Life / Aliphatic Index: 1.9 hour Aliphatic Index: 88.44
Instability Index: 3201.25 Extinction Coefficient cystines: 5625
Absorbance 280nm: 181.45

Literature

  • PubMed ID:  NA
  • Title:  Isolation and characterization of a natriuretic peptide from Crotalus oreganus abyssus (Grand canyon rattlesnake) and its effects on systemic blood pressure and nitrite levels.